AustralieFrV1, Main, Exploration, bibRecord, 005B61

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

Identifieur interne : 005B61 ( Main/Exploration ); précédent : 005B60; suivant : 005B62

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

Auteurs : Liana K. Billings [États-Unis] ; Yi-Hsiang Hsu [États-Unis] ; Rachel J. Ackerman [États-Unis] ; Josee Dupuis [États-Unis] ; Benjamin F. Voight [États-Unis] ; Laura J. Rasmussen-Torvik [États-Unis] ; Serge Hercberg [France] ; Mark Lathrop [France] ; Daniel Barnes [Royaume-Uni] ; Claudia Langenberg [Royaume-Uni] ; JENNIE HUI [Australie] ; MAO FU [États-Unis] ; Nabila Bouatia-Naji [France] ; Cecile Lecoeur [France] ; PING AN [États-Unis] ; Patrik K. Magnusson [Suède] ; Ida Surakka [États-Unis] ; Samuli Ripatti [États-Unis] ; Lene Christiansen [Danemark] ; Christine Dalgard [Danemark] ; Lasse Folkersen [Suède] ; Elin Grundberg [Royaume-Uni] ; Per Eriksson [Suède] ; Jaakko Kaprio [États-Unis] ; KIRSTEN OHM KYVIK ; Nancy L. Pedersen [Suède] ; Ingrid B. Borecki [États-Unis] ; Michael A. Province [Suède] ; Beverley Balkau ; Philippe Froguel [France] ; Alan R. Shuldiner [États-Unis] ; Lyle J. Palmer ; Nick Wareham [Royaume-Uni] ; Pierre Meneton ; Toby Johnson ; James S. Pankow ; David Karasik [États-Unis] ; James B. Meigs [États-Unis] ; Douglas P. Kiel [États-Unis] ; Jose C. Florez [États-Unis]

Source :

Diabetes : (New York, NY) [ 0012-1797 ] ; 2012.

RBID : Pascal:12-0327152

Descripteurs français

Pascal (Inist)
- Os, Gène, Diabète de type 2.

English descriptors

KwdEn :
- Bone, Gene, Type 2 diabetes.

Abstract

Exploring genetic pleiotropy can provide clues to a mechanism underlying the observed epidemiological association between type 2 diabetes and heightened fracture risk. We examined genetic variants associated with bone mineral density (BMD) for association with type 2 diabetes and glycemic traits in large well-phenotyped and -genotyped consortia We undertook follow-up analysis in ∼19,000 individuals and assessed gene expression. We queried single nucleotide polymorphisms (SNPs) associated with BMD at levels of genome-wide significance, variants in linkage disequilibrium (r² > 0.5), and BMD candidate genes. SNP rs6867040, at the ITGA1 locus, was associated with a 0.0166 mmol/L (0.004) increase in fasting glucose per C allele in the combined analysis. Genetic variants in the ITGA1 locus were associated with its expression in the liver but not in adipose tissue. ITGA1 variants appeared among the top loci associated with type 2 diabetes, fasting insulin, β-cell function by homeostasis model assessment, and 2-h post-oral glucose tolerance test glucose and insulin levels. ITGA1 has demonstrated genetic pleiotropy in prior studies, and its suggested role in liver fibrosis, insulin secretion, and bone healing lends credence to its contribution to both osteoporosis and type 2 diabetes. These findings further underscore the link between skeletal and glucose metabolism and highlight a locus to direct future investigations.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402303

Affiliations:

Le document en format XML

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<author><name sortKey="Ping An" sort="Ping An" uniqKey="Ping An" last="Ping An">PING AN</name>
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<author><name sortKey="Magnusson, Patrik K" sort="Magnusson, Patrik K" uniqKey="Magnusson P" first="Patrik K." last="Magnusson">Patrik K. Magnusson</name>
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<author><name sortKey="Christiansen, Lene" sort="Christiansen, Lene" uniqKey="Christiansen L" first="Lene" last="Christiansen">Lene Christiansen</name>
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<author><name sortKey="Dalgard, Christine" sort="Dalgard, Christine" uniqKey="Dalgard C" first="Christine" last="Dalgard">Christine Dalgard</name>
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<author><name sortKey="Folkersen, Lasse" sort="Folkersen, Lasse" uniqKey="Folkersen L" first="Lasse" last="Folkersen">Lasse Folkersen</name>
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<author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institute</s1>
<s2>Stockholm</s2>
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<author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name>
<affiliation wicri:level="4"><inist:fA14 i1="20"><s1>Institute for Molecular Medicine Finland, University of Helsinki</s1>
<s2>Helsinki, Finland</s2>
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<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="Kirsten Ohm Kyvik" sort="Kirsten Ohm Kyvik" uniqKey="Kirsten Ohm Kyvik" last="Kirsten Ohm Kyvik">KIRSTEN OHM KYVIK</name>
</author>
<author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institute</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>16 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name>
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<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Province, Michael A" sort="Province, Michael A" uniqKey="Province M" first="Michael A." last="Province">Michael A. Province</name>
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<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>16 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name>
</author>
<author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>National Center for Scientific Research, UMR 8199, Genomics and Metabolic Diseases, Lille Pasteur Institute, Lille Nord de France University</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name>
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<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name>
</author>
<author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital</s1>
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<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name>
</author>
<author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name>
</author>
<author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name>
</author>
<author><name sortKey="Karasik, David" sort="Karasik, David" uniqKey="Karasik D" first="David" last="Karasik">David Karasik</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Framingham Heart Study</s1>
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<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>38 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
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<s3>USA</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Framingham Heart Study</s1>
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<sZ>2 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
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<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Medicine, Harvard Medical School</s1>
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<s3>USA</s3>
<sZ>1 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Framingham Heart Study</s1>
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<sZ>2 aut.</sZ>
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<sZ>37 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Florez, Jose C" sort="Florez, Jose C" uniqKey="Florez J" first="Jose C." last="Florez">Jose C. Florez</name>
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<sZ>1 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
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<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Medicine, Harvard Medical School</s1>
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<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>38 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
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<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<sZ>5 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits</title>
<author><name sortKey="Billings, Liana K" sort="Billings, Liana K" uniqKey="Billings L" first="Liana K." last="Billings">Liana K. Billings</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Human Genetic Research, Massachusetts General Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Medicine, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hsu, Yi Hsiang" sort="Hsu, Yi Hsiang" uniqKey="Hsu Y" first="Yi-Hsiang" last="Hsu">Yi-Hsiang Hsu</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Framingham Heart Study</s1>
<s2>Framingham, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ackerman, Rachel J" sort="Ackerman, Rachel J" uniqKey="Ackerman R" first="Rachel J." last="Ackerman">Rachel J. Ackerman</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Human Genetic Research, Massachusetts General Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dupuis, Josee" sort="Dupuis, Josee" uniqKey="Dupuis J" first="Josee" last="Dupuis">Josee Dupuis</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Framingham Heart Study</s1>
<s2>Framingham, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Voight, Benjamin F" sort="Voight, Benjamin F" uniqKey="Voight B" first="Benjamin F." last="Voight">Benjamin F. Voight</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Human Genetic Research, Massachusetts General Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Medicine, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Broad Institute of Harvard and Massachusetts Institute of Technology</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rasmussen Torvik, Laura J" sort="Rasmussen Torvik, Laura J" uniqKey="Rasmussen Torvik L" first="Laura J." last="Rasmussen-Torvik">Laura J. Rasmussen-Torvik</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Preventive Medicine, Northwestern University Feinberg School of Medicine</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>INSERM, National Institute of Agronomic Research, University of Paris</s1>
<s2>Bobigny</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Bobigny</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>National Genotyping Center, Atomic Energy Commission, Institute of Genomics</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barnes, Daniel" sort="Barnes, Daniel" uniqKey="Barnes D" first="Daniel" last="Barnes">Daniel Barnes</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jennie Hui" sort="Jennie Hui" uniqKey="Jennie Hui" last="Jennie Hui">JENNIE HUI</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Molecular Genetics, PathWest Laboratory Medicine of Western Australia</s1>
<s2>Nedlands, Western Australia</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Nedlands, Western Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>School of Population Health and School of Pathology and Laboratory Medicine, University of Western Australia</s1>
<s2>Nedlands, Western Australia</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Nedlands, Western Australia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Busselton Population Medical Research Foundation Sir Charles Gairdner Hospital</s1>
<s2>Nedlands, Western Australia</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Busselton Population Medical Research Foundation Sir Charles Gairdner Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mao Fu" sort="Mao Fu" uniqKey="Mao Fu" last="Mao Fu">MAO FU</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Department of Medicine, University of Maryland School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>National Center for Scientific Research, UMR 8199, Genomics and Metabolic Diseases, Lille Pasteur Institute, Lille Nord de France University</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>National Center for Scientific Research, UMR 8199, Genomics and Metabolic Diseases, Lille Pasteur Institute, Lille Nord de France University</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ping An" sort="Ping An" uniqKey="Ping An" last="Ping An">PING AN</name>
<affiliation wicri:level="4"><inist:fA14 i1="18"><s1>Division of Statistical Genomics and Department of Genetics, Washington University School of Medicine</s1>
<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Magnusson, Patrik K" sort="Magnusson, Patrik K" uniqKey="Magnusson P" first="Patrik K." last="Magnusson">Patrik K. Magnusson</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institute</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>16 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Surakka, Ida" sort="Surakka, Ida" uniqKey="Surakka I" first="Ida" last="Surakka">Ida Surakka</name>
<affiliation wicri:level="4"><inist:fA14 i1="20"><s1>Institute for Molecular Medicine Finland, University of Helsinki</s1>
<s2>Helsinki, Finland</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Public Health Genomics Unit, National Institute for Health and Welfare</s1>
<s2>Helsinki, Finland</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Helsinki, Finland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ripatti, Samuli" sort="Ripatti, Samuli" uniqKey="Ripatti S" first="Samuli" last="Ripatti">Samuli Ripatti</name>
<affiliation wicri:level="4"><inist:fA14 i1="20"><s1>Institute for Molecular Medicine Finland, University of Helsinki</s1>
<s2>Helsinki, Finland</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Public Health Genomics Unit, National Institute for Health and Welfare</s1>
<s2>Helsinki, Finland</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Helsinki, Finland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Christiansen, Lene" sort="Christiansen, Lene" uniqKey="Christiansen L" first="Lene" last="Christiansen">Lene Christiansen</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark</s1>
<s2>Odense</s2>
<s3>DNK</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Odense</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dalgard, Christine" sort="Dalgard, Christine" uniqKey="Dalgard C" first="Christine" last="Dalgard">Christine Dalgard</name>
<affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark</s1>
<s2>Odense</s2>
<s3>DNK</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Odense</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Folkersen, Lasse" sort="Folkersen, Lasse" uniqKey="Folkersen L" first="Lasse" last="Folkersen">Lasse Folkersen</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institute</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grundberg, Elin" sort="Grundberg, Elin" uniqKey="Grundberg E" first="Elin" last="Grundberg">Elin Grundberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Wellcome Trust Sanger Institute</s1>
<s2>Hinxton</s2>
<s3>GBR</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Wellcome Trust Sanger Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Atherosclerosis Research Unit, Department of Medicine, Karolinska Institute</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kaprio, Jaakko" sort="Kaprio, Jaakko" uniqKey="Kaprio J" first="Jaakko" last="Kaprio">Jaakko Kaprio</name>
<affiliation wicri:level="4"><inist:fA14 i1="20"><s1>Institute for Molecular Medicine Finland, University of Helsinki</s1>
<s2>Helsinki, Finland</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="Kirsten Ohm Kyvik" sort="Kirsten Ohm Kyvik" uniqKey="Kirsten Ohm Kyvik" last="Kirsten Ohm Kyvik">KIRSTEN OHM KYVIK</name>
</author>
<author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L." last="Pedersen">Nancy L. Pedersen</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institute</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>16 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name>
<affiliation wicri:level="4"><inist:fA14 i1="18"><s1>Division of Statistical Genomics and Department of Genetics, Washington University School of Medicine</s1>
<s2>St. Louis, Missouri</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Province, Michael A" sort="Province, Michael A" uniqKey="Province M" first="Michael A." last="Province">Michael A. Province</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Medical Epidemiology and Biostatistics, Karolinska Institute</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>16 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name>
</author>
<author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>National Center for Scientific Research, UMR 8199, Genomics and Metabolic Diseases, Lille Pasteur Institute, Lille Nord de France University</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Department of Medicine, University of Maryland School of Medicine</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name>
</author>
<author><name sortKey="Wareham, Nick" sort="Wareham, Nick" uniqKey="Wareham N" first="Nick" last="Wareham">Nick Wareham</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meneton, Pierre" sort="Meneton, Pierre" uniqKey="Meneton P" first="Pierre" last="Meneton">Pierre Meneton</name>
</author>
<author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name>
</author>
<author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S." last="Pankow">James S. Pankow</name>
</author>
<author><name sortKey="Karasik, David" sort="Karasik, David" uniqKey="Karasik D" first="David" last="Karasik">David Karasik</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Framingham Heart Study</s1>
<s2>Framingham, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Medicine, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Framingham Heart Study</s1>
<s2>Framingham, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kiel, Douglas P" sort="Kiel, Douglas P" uniqKey="Kiel D" first="Douglas P." last="Kiel">Douglas P. Kiel</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Medicine, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Hebrew SeniorLife Institute for Aging Research and Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Framingham Heart Study</s1>
<s2>Framingham, Massachusetts</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Florez, Jose C" sort="Florez, Jose C" uniqKey="Florez J" first="Jose C." last="Florez">Jose C. Florez</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for Human Genetic Research, Massachusetts General Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Medicine, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Broad Institute of Harvard and Massachusetts Institute of Technology</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Diabetes : (New York, NY)</title>
<title level="j" type="abbreviated">Diabetes : (N.Y. NY)</title>
<idno type="ISSN">0012-1797</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Diabetes : (New York, NY)</title>
<title level="j" type="abbreviated">Diabetes : (N.Y. NY)</title>
<idno type="ISSN">0012-1797</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bone</term>
<term>Gene</term>
<term>Type 2 diabetes</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Os</term>
<term>Gène</term>
<term>Diabète de type 2</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Exploring genetic pleiotropy can provide clues to a mechanism underlying the observed epidemiological association between type 2 diabetes and heightened fracture risk. We examined genetic variants associated with bone mineral density (BMD) for association with type 2 diabetes and glycemic traits in large well-phenotyped and -genotyped consortia We undertook follow-up analysis in ∼19,000 individuals and assessed gene expression. We queried single nucleotide polymorphisms (SNPs) associated with BMD at levels of genome-wide significance, variants in linkage disequilibrium (r<sup>2</sup>
 > 0.5), and BMD candidate genes. SNP rs6867040, at the ITGA1 locus, was associated with a 0.0166 mmol/L (0.004) increase in fasting glucose per C allele in the combined analysis. Genetic variants in the ITGA1 locus were associated with its expression in the liver but not in adipose tissue. ITGA1 variants appeared among the top loci associated with type 2 diabetes, fasting insulin, β-cell function by homeostasis model assessment, and 2-h post-oral glucose tolerance test glucose and insulin levels. ITGA1 has demonstrated genetic pleiotropy in prior studies, and its suggested role in liver fibrosis, insulin secretion, and bone healing lends credence to its contribution to both osteoporosis and type 2 diabetes. These findings further underscore the link between skeletal and glucose metabolism and highlight a locus to direct future investigations.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Danemark</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Hauts-de-France</li>
<li>Illinois</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Missouri (État)</li>
<li>Nord-Pas-de-Calais</li>
<li>Svealand</li>
<li>Uusimaa</li>
<li>Île-de-France</li>
</region>
<settlement><li>Bobigny</li>
<li>Helsinki</li>
<li>Lille</li>
<li>Saint-Louis (Missouri)</li>
<li>Stockholm</li>
<li>Évry (Essonne)</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
<li>École de médecine (Université Washington de Saint-Louis)</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name>
<name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name>
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<country name="Danemark"><noRegion><name sortKey="Christiansen, Lene" sort="Christiansen, Lene" uniqKey="Christiansen L" first="Lene" last="Christiansen">Lene Christiansen</name>
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   |texte=   Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
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Serveur d'exploration sur les relations entre la France et l'Australie

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

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	Serveur d'exploration sur les relations entre la France et l'Australie
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